Cohen Ira L, Tsiouris John A
Dept. of Psychology and George A. Jervis Clinic, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA.
J Autism Dev Disord. 2006 Nov;36(8):1077-88. doi: 10.1007/s10803-006-0145-7.
A quantitative examination was made of the association of parental mood and anxiety disorders with severity of disability within a large sample of young children with Pervasive Developmental Disorder (PDD). Maternal recurrent mood disorders were associated with elevated cognitive and adaptive functioning in their affected children, parent reports of increased behavior problems and teacher reports of an internalizing behavioral style. Maternal histories of anxiety disorders and paternal depression or anxiety disorders were not associated with levels of adaptive/cognitive functioning or levels of maladaptive behaviors in the children. Various genetic models are discussed. It is hypothesized that genes associated with recurrent depression in women may exert a "protective" effect on cognition and adaptive functioning in children with PDD.
对大量广泛性发育障碍（PDD）幼儿样本中父母的情绪和焦虑症与残疾严重程度之间的关联进行了定量研究。母亲复发性情绪障碍与受影响儿童的认知和适应性功能提高、父母报告的行为问题增加以及教师报告的内化行为方式有关。母亲的焦虑症病史以及父亲的抑郁症或焦虑症病史与儿童的适应性/认知功能水平或适应不良行为水平无关。讨论了各种遗传模型。据推测，与女性复发性抑郁症相关的基因可能对PDD儿童的认知和适应性功能产生“保护”作用。
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