Efficacy of voriconazole in experimental Cryptococcus neoformans infection.
作者信息
Mavrogiorgos Nikolaos, Zaragoza Oscar, Casadevall Arturo, Nosanchuk Joshua D
机构信息
Department of Microbiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
出版信息
Mycopathologia. 2006 Aug;162(2):111-4. doi: 10.1007/s11046-006-0039-4.
PMID:16897589
Abstract
Voriconazole is a third generation triazole with improved activity against many fungal pathogens. We examined the efficacy of voriconazole in a murine infection model and evaluated the drug's effect on cellular characteristics and serum polysaccharide levels. The antifungal reduced serum polysaccharide and significantly prolonged the survival of lethally infected animals.
摘要
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