Siddique M Atif, Hartman Kelly E, Dragileva Ella, Dondero Marla, Gebretsadik Tebeb, Shintani Ayumi, Peiperl Laurence, Valentine Fred, Kalams Spyros A
Department of Medicine, Infectious Diseases Unit, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
J Infect Dis. 2006 Sep 1;194(5):661-5. doi: 10.1086/505913. Epub 2006 Jul 28.
The influence of CD4(+) T cell nadirs on human immunodeficiency virus (HIV)-specific immune responses in subjects with apparently normal CD4(+) T cell counts is not known. We evaluated the frequency of HIV-1-specific immune responses in a cohort of patients with complete viral suppression (HIV-1 RNA load, <50 copies/mL) who were receiving highly active antiretroviral therapy and had a wide range of CD4(+) T cell nadirs. We found positive associations between CD4(+) T cell nadirs and the magnitude of HIV-specific CD8(+) T cell responses (P=.02) and of T cell helper responses (P=.04). These data show the CD4(+) T cell nadir to be an independent predictor of HIV-specific CD4(+) and CD8(+) T cell responses in HIV-1-infected subjects with optimal suppression of viremia.
在CD4(+) T细胞计数看似正常的受试者中，CD4(+) T细胞最低点对人类免疫缺陷病毒（HIV）特异性免疫反应的影响尚不清楚。我们评估了一组接受高效抗逆转录病毒治疗且病毒得到完全抑制（HIV-1 RNA载量，<50拷贝/毫升）、CD4(+) T细胞最低点范围广泛的患者中HIV-1特异性免疫反应的频率。我们发现CD4(+) T细胞最低点与HIV特异性CD8(+) T细胞反应的强度（P = 0.02）以及T细胞辅助反应的强度（P = 0.04）之间存在正相关。这些数据表明，在病毒血症得到最佳抑制的HIV-1感染受试者中，CD4(+) T细胞最低点是HIV特异性CD4(+)和CD8(+) T细胞反应的独立预测指标。
