与自然杀伤细胞淋巴细胞增多症相关的严重蚊虫叮咬超敏反应。

Severe hypersensitivity to mosquito bites associated with natural killer cell lymphocytosis.

作者信息

Tokura Y, Tamura Y, Takigawa M, Koide M, Satoh T, Sakamoto T, Horiguchi D, Yamada M

机构信息

Department of Dermatology, Hamamatsu University School of Medicine, Japan.

出版信息

Arch Dermatol. 1990 Mar;126(3):362-8.

PMID:1689990

Abstract

A 2-year-old girl showed exaggerated skin reactions to mosquito bites and associated general symptoms, including a high temperature, lymphadenopathy, and hepatosplenomegaly. Peripheral blood lymphocytes contained a high percentage of CD2+, CD3-, CD4-, CD8-, CD11b+, CD16+, CD38+, CD56+, CD57-, and HLA-DR+ large granular lymphocytes that exhibited a marked natural killer cell activity. Immunohistochemically, biopsy specimens taken from the lesional skin demonstrated an infiltrate of the cells bearing the natural killer cell phenotype, indicating a role of these cells in the development of the abnormal skin reactions to mosquito bites and other systemic manifestations. Our case suggests that natural killer cell lymphocytosis may show severe hypersensitivity to mosquito bites as the most outstanding manifestation.

摘要

一名2岁女童对蚊虫叮咬表现出过度的皮肤反应及相关全身症状，包括高热、淋巴结病和肝脾肿大。外周血淋巴细胞中CD2 +、CD3 -、CD4 -、CD8 -、CD11b +、CD16 +、CD38 +、CD56 +、CD57 -和HLA - DR +大颗粒淋巴细胞的比例很高，这些细胞表现出显著的自然杀伤细胞活性。免疫组织化学检测显示，取自皮损处的活检标本有自然杀伤细胞表型的细胞浸润，表明这些细胞在蚊虫叮咬异常皮肤反应及其他全身表现的发生中起作用。我们的病例提示，自然杀伤细胞淋巴细胞增多症可能以对蚊虫叮咬的严重超敏反应为最突出表现。