Kuroda Hajime, Toyozumi Yasuo, Masuda Tomoko, Ougida Tomohiko, Hanami Kyota, Kyoko Kiuchi, Tamaru Jun-ichi, Itoyama Shinji
Department of Pathology, Saitama Medical Center, Saitama Medical School, Saitama, Japan.
Acta Cytol. 2006 Jul-Aug;50(4):418-22. doi: 10.1159/000325985.
To analyze the cytologic features, estrogen and progesterone receptors, and Her2/neu protein in glassy cell carcinoma (GCC) of the cervix.
Cases were analyzed using various parameters, including age at presentation, stage, treatment and clinical course. Between 1990 and 2003, patients with primary cervical carcinomas were treated and cytopathologic analyses performed. Tests for estrogen receptor (ER), progesterone receptor (PR) and Her2/neu protein were performed on paraffin sections.
GCC of the cervix is composed of large cells with abundant chromatin, which gives them their characteristic glassy appearance. Eleven cases were identified as GCC. One case (9.1%) was correctly diagnosed from the cervicovaginal smear. Among the GCC cases, ER, PR and Her2/neu were positive in 2 (18.1%), 1 (9.1%) and 5 (45.4%) cases, respectively.
Cytology of GCC reveals characteristic features that differ from those of other carcinomas of the cervix. GCC has unique cytologic characteristics and causes diagnostic confusion, possibly leading to incorrect diagnoses. The reason for such low diagnostic precision in cytology might be due to the lack of differentiation and low frequency of this tumor. Our results, demonstrating Her2/ neu overexpression, may correlate with more aggressive behavior and a worse clinical outcome.
分析宫颈玻璃样细胞癌（GCC）的细胞学特征、雌激素和孕激素受体以及Her2/neu蛋白。
使用包括就诊年龄、分期、治疗和临床病程等各种参数对病例进行分析。1990年至2003年间，对原发性宫颈癌患者进行治疗并进行细胞病理学分析。在石蜡切片上进行雌激素受体（ER）、孕激素受体（PR）和Her2/neu蛋白检测。
宫颈GCC由具有丰富染色质的大细胞组成，这赋予它们特征性的玻璃样外观。共鉴定出11例GCC。1例（9.1%）通过宫颈阴道涂片被正确诊断。在GCC病例中，ER、PR和Her2/neu阳性分别为2例（18.1%）、1例（9.1%）和5例（45.4%）。
GCC的细胞学表现出与其他宫颈癌不同的特征。GCC具有独特的细胞学特征，会造成诊断混淆，可能导致误诊。细胞学诊断准确率如此之低的原因可能是该肿瘤缺乏分化且发病率低。我们的结果显示Her2/neu过表达，这可能与更具侵袭性的行为和更差的临床结局相关。
