Yoon Nara, Kim Ji-Ye, Kim Hyun-Soo
Department of Pathology, The Catholic University of Korea Incheon St. Mary's Hospital, Incheon, Republic of Korea.
Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Oncotarget. 2016 Nov 29;7(48):78448-78454. doi: 10.18632/oncotarget.12905.
We performed a retrospective analysis of the clinical features and patient outcomes for advanced-stage glassy cell carcinoma of the uterine cervix. The study was restricted to cases in which the glassy cell features constituted at least 95% of the biopsied specimen. During the study period, 675 patients were diagnosed with primary cervical carcinoma. Five (0.7%) of the 675 patients had cervical glassy cell carcinoma; of these, three were premenopausal, and two were postmenopausal. Abnormal vaginal bleeding was the most frequent presenting symptom. Glassy cell carcinoma presented as a fungating, exophytic, or infiltrative mass. The greatest tumor dimension ranged from 3 to 9 cm. All patients had parametrial extension. Four patients had stage IIB tumors, and one had a stage IIIB tumor. All patients received concurrent chemoradiation therapy. The patient with a stage IIIB tumor died of hypovolemic shock caused by upper gastrointestinal bleeding during radiation therapy. Three patients with stage IIB tumors survived for more than 8 years without tumor recurrence or metastasis. One of these three patients died of pelvic recurrence 10 years after the initial diagnosis. Cervical glassy cell carcinoma has traditionally been considered an aggressive, highly malignant tumor with poor prognosis, but our data suggest that patient survival is not significantly decreased compared with other histological types of cervical carcinoma. It will be necessary to analyze patient outcomes using a larger number of cervical glassy cell carcinoma cases to confirm our findings.
我们对晚期子宫颈玻璃样细胞癌的临床特征和患者预后进行了回顾性分析。该研究仅限于玻璃样细胞特征在活检标本中至少占95%的病例。在研究期间，675例患者被诊断为原发性宫颈癌。675例患者中有5例（0.7%）患有宫颈玻璃样细胞癌；其中3例为绝经前患者，2例为绝经后患者。异常阴道出血是最常见的症状。玻璃样细胞癌表现为蕈伞状、外生性或浸润性肿块。肿瘤最大直径为3至9厘米。所有患者均有宫旁组织浸润。4例患者为IIB期肿瘤，1例为IIIB期肿瘤。所有患者均接受同步放化疗。1例IIIB期肿瘤患者在放疗期间死于上消化道出血引起的低血容量休克。3例IIB期肿瘤患者存活超过8年，无肿瘤复发或转移。这3例患者中的1例在初次诊断后10年死于盆腔复发。传统上，宫颈玻璃样细胞癌被认为是一种侵袭性强、恶性程度高、预后差的肿瘤，但我们的数据表明，与其他组织学类型的宫颈癌相比，患者生存率并未显著降低。有必要分析更多宫颈玻璃样细胞癌病例的患者预后，以证实我们的发现。
