Pantanowitz Liron, Galan Anjela, Gang David L, Crisi Giovanna M, LaPolice Paula, Goulart Robert A
Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, Massachusetts 01199, USA.
Acta Cytol. 2006 Jul-Aug;50(4):460-5. doi: 10.1159/000325993.
The cytologic features of melanotic neuroectodermal tumor of infancy (MNTI) have been described in rare cases only, and these reports have been based solely on direct smears obtained from aspirated tumor material or from touch preparations of resected tumors.
We report, to our knowledge, the first documented case of an epididymal MNTI diagnosed from aspirated hydrocele fluid processed using the ThinPrep system (Cytyc Corp., Boxborough, Massachusetts, U.S.A.).
Based on a 15 year retrospective review of scrotal fluids submitted for cytologic evaluation to our laboratory, MNTI represented the sole neoplasm that was represented in the fluid and could be specifically diagnosed. Compared to the direct smear evaluation in our case and other published reports, the ThinPrep method enables the recognition of both neuroblast-like cells and larger melanin-containing epithelial cells in scrotal fluid, thereby aiding in the specific diagnosis of MNTI and minimizing the risk of misdiagnosing this tumor as a more aggressive neoplasm.
婴儿黑色素性神经外胚层肿瘤（MNTI）的细胞学特征仅在少数病例中有描述，且这些报告仅基于从抽吸的肿瘤材料或切除肿瘤的触摸涂片获得的直接涂片。
据我们所知，我们报告了首例经ThinPrep系统（美国马萨诸塞州博克斯伯勒的Cytyc公司）处理的抽吸鞘膜积液中诊断出的附睾MNTI病例。
基于对提交至我们实验室进行细胞学评估的阴囊液进行的15年回顾性研究，MNTI是该液体中唯一出现且可被明确诊断的肿瘤。与我们病例及其他已发表报告中的直接涂片评估相比，ThinPrep方法能够识别阴囊液中的神经母细胞样细胞和含黑色素的较大上皮细胞，从而有助于MNTI的明确诊断，并将该肿瘤误诊为侵袭性更强肿瘤的风险降至最低。
