Toda T, Sadi A M, Kiyuna M, Egawa H, Tamamoto T, Toyoda Z
Department of Clinical Laboratory Medicine, School of Medicine, University of the Ryukyus, Okinawa, Japan.
Acta Cytol. 1998 May-Jun;42(3):775-80. doi: 10.1159/000331845.
Pigmented neuroectodermal tumor of infancy (PNTI) is a rare pigmentary tumor. Cytologic study of this tumor had not been performed before. In the present study, cytology of such a tumor was done in addition to histology, electron microscopy and immunohistochemistry.
A 5-month-old infant had a scrotal tumor. After tumorectomy, touch smear for cytology revealed small and large tumor cells. The small cells showed a high nuclear/cytoplasmic ratio, and the large cells contained pigment in their cytoplasm. Histologically, the small cells and large, pigmented cells showed a typical alveolar and tubular pattern, respectively. The small cells neuroblastlike and the large cells showed melanocytelike features ultrastructurally and immunohistochemically.
Cytology has not been applied to the diagnoses of PNTI. In our opinion, fine needle aspiration cytology could be helpful in the preoperative diagnosis of this tumor.
婴儿色素性神经外胚层肿瘤（PNTI）是一种罕见的色素性肿瘤。此前尚未对该肿瘤进行细胞学研究。在本研究中，除了组织学、电子显微镜检查和免疫组织化学外，还对这种肿瘤进行了细胞学检查。
一名5个月大的婴儿患有阴囊肿瘤。肿瘤切除术后，用于细胞学检查的触摸涂片显示有小的和大的肿瘤细胞。小细胞的核质比高，大细胞的细胞质中含有色素。组织学上，小细胞和大的色素细胞分别显示出典型的肺泡状和管状结构。小细胞呈神经母细胞样，大细胞在超微结构和免疫组织化学上显示出黑素细胞样特征。
细胞学尚未应用于PNTI的诊断。我们认为，细针穿刺细胞学检查有助于该肿瘤的术前诊断。
