Albano Vincenzo Giulio, Bandini Marco, Monari Magda, Marcucci Eleonora, Piccinelli Fabio, Umani-Ronchi Achille
Dipartimento di Chimica G. Ciamician, Università di Bologna. Via Selmi, 2 40126 Bologna, Italy.
J Org Chem. 2006 Aug 18;71(17):6451-8. doi: 10.1021/jo060767v.
New chiral chelating C2 bis-oxazoline-amide ligands (1) exhibiting a highly flexible molecular structure have been prepared in high yield through a versatile synthetic pathway. Combined crystallographic, variable temperature (VT)-NMR, IR, and ESI-MS studies have been carried out to investigate the nature of the 1-Pd complexes that are effective tools in controlling the stereochemical outcome of Pd-catalyzed allylic alkylations (ee up to 98%).
通过一种通用的合成途径，已高收率制备出具有高度灵活分子结构的新型手性螯合C2双恶唑啉-酰胺配体（1）。已开展结合晶体学、变温（VT）-核磁共振、红外光谱和电喷雾电离质谱的研究，以探究1-Pd配合物的性质，这些配合物是控制钯催化烯丙基烷基化立体化学结果的有效工具（对映体过量高达98%）。
