Institut für Organische Chemie, Universität des Saarlandes, D-66123, Saarbrücken, Germany.
Org Biomol Chem. 2011 Feb 7;9(3):872-80. doi: 10.1039/c0ob00628a. Epub 2010 Dec 1.
Pd-catalyzed allylations are an excellent tool for stereoselective peptide modifications, being clearly superior to normal alkylations. The reactions proceed not only in high yield, but also high regio- and diastereoselectivities, and trans-products are formed exclusively. Therefore, this is a powerful synthetic tool for natural product and drug synthesis.
Pd 催化的烯丙基化是立体选择性肽修饰的极好工具,明显优于普通烷基化。反应不仅产率高,而且区域和立体选择性高,并且仅形成反式产物。因此,这是天然产物和药物合成的有力合成工具。