Li L-F, Ma C
Department of Dermatology, Peking University Third Hospital, Beijing, China.
Clin Exp Dermatol. 2006 Sep;31(5):642-7. doi: 10.1111/j.1365-2230.2006.02185.x.
An epidemiological study of severe cutaneous adverse drug reactions (SCADRs) in China has not been reported.
To estimate the incidence of SCADRs in a city district of China.
A retrospective study was performed in Peking University Third Hospital, the only hospital in Haidian district, Beijing with a dermatology ward. The medical records of inpatients with SCADRs from January 1994 to December 2002 were studied.
The prevalence rates for overall SCADRs, Stevens-Johnson syndrome (SJS), exfoliative dermatitis (ED), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) among hospitalized patients were 0.32, 0.15, 0.10, 0.04 and 0.07 per thousand, respectively. The risk of SCADRs from systemic drugs among hospitalized patients was 0.03/1000 (0.02/1000 for SJS, and 0.01/1000 for ED and DRESS). The reported incidence of SCADRs in Haidian district was not less than 1.8 per million person-years. The reported incidence of ED, SJS, TEN and DRESS in Haidian district was not less than 0.6, 0.8, 0.05 and 0.4 per million person-years, respectively. The most common underlying disorders were infection, pain-related diseases and epilepsy. Antibiotics were the most common offending drugs followed by anticonvulsants and traditional Chinese medicines (TCM).
These results confirm the relatively low incidence of SCADRs in China. Antibiotics, anticonvulsants and TCM are the most common causative drugs.
中国尚未有关于严重皮肤不良反应（SCADRs）的流行病学研究报道。
评估中国某城区SCADRs的发病率。
在北京大学第三医院进行了一项回顾性研究，该医院是北京市海淀区唯一设有皮肤科病房的医院。研究了1994年1月至2002年12月期间SCADRs住院患者的病历。
住院患者中，总体SCADRs、史蒂文斯-约翰逊综合征（SJS）、剥脱性皮炎（ED）、中毒性表皮坏死松解症（TEN）以及伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS）的患病率分别为千分之0.32、0.15、0.10、0.04和0.07。住院患者中系统性药物引起的SCADRs风险为0.03/1000（SJS为0.02/1000，ED和DRESS为0.01/1000）。海淀区报告的SCADRs发病率不少于1.8/百万人口年。海淀区报告的ED、SJS、TEN和DRESS发病率分别不少于0.6/百万人口年、0.8/百万人口年、0.05/百万人口年和0.4/百万人口年。最常见的基础疾病是感染、疼痛相关疾病和癫痫。抗生素是最常见的致病药物，其次是抗惊厥药和中药（TCM）。
这些结果证实了中国SCADRs的发病率相对较低。抗生素、抗惊厥药和中药是最常见的致病药物。
