Shukla Neerav N, Trippett Tanya M
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Curr Oncol Rep. 2006 Sep;8(5):387-94. doi: 10.1007/s11912-006-0062-0.
Lymphoma is the third most common cancer in children and adolescents. Non-Hodgkin's lymphomas comprise a heterogeneous group of tumors with distinct pathologic and clinical characteristics. Over the past three decades, significant advancements have been made in the molecular characterization of these disorders. With the use of intensive multiagent chemotherapy, non-Hodgkin's lymphomas are now among the most successfully treated cancers in the pediatric population. Future goals of therapy include reduction of treatment duration for early-stage patients and identification of novel targets and therapeutics for advanced-stage patients.
淋巴瘤是儿童和青少年中第三常见的癌症。非霍奇金淋巴瘤由一组具有不同病理和临床特征的异质性肿瘤组成。在过去三十年中，这些疾病的分子特征研究取得了重大进展。通过使用强化多药化疗，非霍奇金淋巴瘤现在是儿科人群中治疗最成功的癌症之一。未来的治疗目标包括缩短早期患者的治疗时间，以及为晚期患者确定新的靶点和治疗方法。
