Allen-Auerbach Martin, Quon Andrew, Weber Wolfgang A, Obrzut Sebastian, Crawford Tyler, Silverman Daniel H S, Ratib Osman, Phelps Michael E, Czernin Johannes
Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, UCLA David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-6942 USA.
Mol Imaging Biol. 2004 Nov-Dec;6(6):411-6. doi: 10.1016/j.mibio.2004.08.004.
2-Deoxy-2-[18F]fluoro-D-Glucose positron emission tomography (FDG-PET) stages patients with Hodgkin's disease (HD) and Non-Hodgkin's lymphoma (NHL) with higher accuracy than computed tomography (CT). We sought to determine whether integrated (hardware) fused PET/CT imaging results in further improvements in staging accuracy.
Seventy-three patients (age 51 +/- 17 years, 37 female, 36 male) with HD (n = 20) or NHL (n = 53) undergoing staging were studied with an integrated PET/CT system. Image findings were verified by clinical follow up, additional imaging and when available, histology.
Thirty-four of 73 patients (46.5%) had evidence of disease and 39 were disease free as confirmed by clinical evaluation and follow-up for 41 +/- 22 weeks (n = 73), including biopsy (n = 26), and other imaging modalities (n = 52) when available. A discordant image interpretation between PET and PET/CT occurred in seven patients (10%). PET/CT correctly upstaged two and downstaged five patients. Overall staging was accurate in 93% with PET/CT and 84% with PET (P = 0.03).
Lymphoma is staged with higher accuracy using PET/CT than PET alone.
2-脱氧-2-[18F]氟-D-葡萄糖正电子发射断层扫描（FDG-PET）对霍奇金病（HD）和非霍奇金淋巴瘤（NHL）患者进行分期的准确性高于计算机断层扫描（CT）。我们试图确定一体化（硬件）融合PET/CT成像是否能进一步提高分期准确性。
使用一体化PET/CT系统对73例接受分期检查的HD患者（n = 20）或NHL患者（n = 53）进行研究（年龄51±17岁，女性37例，男性36例）。通过临床随访、额外的影像学检查以及（如有）组织学检查来验证图像结果。
73例患者中有34例（46.5%）有疾病证据，39例无疾病，经41±22周（n = 73）的临床评估和随访证实，包括活检（n = 26）以及（如有）其他影像学检查（n = 52）。7例患者（10%）PET与PET/CT的图像解读不一致。PET/CT正确地将2例患者分期上调，5例患者分期下调。PET/CT总体分期准确率为93%，PET为84%（P = 0.03）。
使用PET/CT对淋巴瘤进行分期的准确性高于单独使用PET。
