抗人淋巴细胞分化抗原CD 76的单克隆抗体与神经节苷脂结合。
Monoclonal antibodies against the human lymphocyte differentiation antigen CD 76 bind to gangliosides.
作者信息
Kniep B, Mühlradt P F, Dörken B, Moldenhauer G, Vilella R, Schwartz-Albiez R
机构信息
GBF-Institute for Biotechnological Research, Braunschweig, FRG.
出版信息
FEBS Lett. 1990 Feb 26;261(2):347-9. doi: 10.1016/0014-5793(90)80588-a.
Two monoclonal antibodies, HD 66 and CRIS-4, by which the new CD 76 B-cell-associated cluster was defined, bound to several gangliosides (sialic acid containing glycolipids) of different polarity. One of the gangliosides recognized by HD 66 could be identified as NeuAc alpha 2-6Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc-beta 1-1'Cer. This antigen was enzymatically synthesized. Sialidase treatment of the ganglioside antigens abolished binding of HD 66 and CRIS-4.
两种单克隆抗体HD 66和CRIS - 4定义了新的CD 76 B细胞相关簇，它们可与几种不同极性的神经节苷脂（含唾液酸的糖脂）结合。HD 66识别的一种神经节苷脂可鉴定为NeuAcα2 - 6Galβ1 - 4GlcNAcβ1 - 3Galβ1 - 4Glc - β1 - 1'Cer。该抗原是通过酶促合成的。对神经节苷脂抗原进行唾液酸酶处理后，HD 66和CRIS - 4的结合被消除。
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