CDw60抗体与神经节苷脂GD3的乙酰化形式结合。
CDw 60 antibodies bind to acetylated forms of ganglioside GD3.
作者信息
Kniep B, Peter-Katalinić J, Flegel W, Northoff H, Rieber E P
机构信息
GBF-Gesellschaft für Biotechnologische Forschung mbH, Braunschweig, FRG.
出版信息
Biochem Biophys Res Commun. 1992 Sep 30;187(3):1343-9. doi: 10.1016/0006-291x(92)90450-y.
PMID:1417810
Abstract
Four monoclonal antibodies, M-T21, M-T32, M-T41 and UM4D4, which belong to the new CDw 60 cluster of antibodies specific for a subpopulation of human T-lymphocytes, were found to bind mainly to acetylated forms of ganglioside GD3. After O-deacetylation of the antigen, binding was reduced ("M-T"-antibodies) or abolished (UM4D4).
摘要
四种单克隆抗体，即M-T21、M-T32、M-T41和UM4D4，属于针对人类T淋巴细胞亚群的新型CDw 60抗体簇，发现它们主要与神经节苷脂GD3的乙酰化形式结合。抗原进行O-脱乙酰化后，结合能力降低（“M-T”抗体）或消失（UM4D4）。
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