Payne-James J J, Spiller R C, Misiewicz J J, Silk D B
Department of Gastroenterology and Nutrition, Central Middlesex Hospital, London, United Kingdom.
Gastrointest Endosc. 1990 Jan-Feb;36(1):43-6. doi: 10.1016/s0016-5107(90)70921-2.
Eleven patients with dysphagia caused by inoperable, unresectable, or recurrent esophagogastric cancer were treated by endoscopic injection of ethanol (with or without per-oral dilation) to induce tumor necrosis. Prior to treatment, patients had a mean dysphagia grade of 3. After one treatment, dysphagia grade had improved to a mean of 1.5. An optimum dysphagia grade (mean, 0.9) was achieved after a mean of 1.6 injection treatments. Treatments were repeated as symptoms recurred, with a mean period between repeat treatments of 32 days (median, 26). There were no complications associated with ethanol-induced tumor necrosis (ETN). Mean patient survival was 140 days (median, 109). These results suggest that ETN has considerable potential for palliation of malignant dysphagia in selected patients.
11例因无法手术、不可切除或复发性食管胃癌导致吞咽困难的患者接受了内镜下注射乙醇（伴或不伴经口扩张）以诱导肿瘤坏死的治疗。治疗前，患者吞咽困难平均分级为3级。经过一次治疗后，吞咽困难分级改善至平均1.5级。平均1.6次注射治疗后达到最佳吞咽困难分级（平均0.9级）。随着症状复发重复进行治疗，重复治疗之间的平均间隔时间为32天（中位数为26天）。没有与乙醇诱导的肿瘤坏死（ETN）相关的并发症。患者平均生存期为140天（中位数为109天）。这些结果表明，ETN在选定患者中对缓解恶性吞咽困难具有相当大的潜力。
