Fujii H, Takada T, Nemoto K, Yamashita T, Abe F, Fujii A, Takeuchi T
Research Laboratories, Nippon Kayaku Co., Ltd., Tokyo, Japan.
J Antibiot (Tokyo). 1990 Feb;43(2):213-9. doi: 10.7164/antibiotics.43.213.
The effect of deoxyspergualin (DSG, NKT-01) on humoral immunity was investigated both in vitro and in vivo. DSG inhibited the primary and secondary responses to T cell-dependent antigens and the response to T cell-independent antigens in thymic and athymic mice. However, natural antibodies in non-sensitized mice were affected less by the administration of DSG. The agent produced a dose-dependent inhibition of B cell proliferation and antibody production to lipopolysaccharide in vitro. Suppression of secondary antibody response was also shown, whenever antigen stimulation was not given, antibody production was not affected. These results suggest that DSG affects the proliferative stage of B lymphocytes in such a way as to inhibit their growth and antibody production.
研究了去氧精胍菌素（DSG，NKT - 01）对体液免疫的体内外作用。DSG抑制胸腺和无胸腺小鼠对T细胞依赖性抗原的初次和二次反应以及对T细胞非依赖性抗原的反应。然而，未致敏小鼠的天然抗体受DSG给药的影响较小。该药物在体外对B细胞增殖和对脂多糖的抗体产生具有剂量依赖性抑制作用。还显示出对二次抗体反应的抑制，只要不给予抗原刺激，抗体产生就不受影响。这些结果表明，DSG以抑制B淋巴细胞生长和抗体产生的方式影响其增殖阶段。
