去氧精胍菌素对小鼠单核吞噬细胞系统的影响。

Influence of deoxyspergualin on mononuclear phagocytic system in mice.

作者信息

Asano K, Muramatsu K, Okamoto K

机构信息

Department of Medical Biology, School of Medicine, Showa University, Tokyo, Japan.

出版信息

Life Sci. 1996;58(10):PL 171-5. doi: 10.1016/0024-3205(96)00022-7.

DOI:10.1016/0024-3205(96)00022-7

PMID:8602108

Abstract

The influence of deoxyspergualin (DSG) on mononuclear phagocytic system was examined in BALB/c mice. DSG did not influence on both the organ distribution of sheep red blood cells (SRBC) and blood clearance of colloidal carbon when the agent was administered intraperitoneally into mice at doses of 5.0 and 10.0 mg/kg for six consecutive days before antigen. Hemagglutination titers in experimental and control mice did not differ significantly when 10.0 mg/kg of DSG was given six times before SRBC injection. However, when administered during the course of the response (days 0 to 5) DSG (5.0 mg/kg/day) markedly suppressed antibody formation.

摘要

在BALB/c小鼠中检测了去氧精胍菌素（DSG）对单核吞噬细胞系统的影响。在抗原注射前连续6天以5.0和10.0 mg/kg的剂量腹腔注射该药物时，DSG对绵羊红细胞（SRBC）的器官分布和胶体碳的血液清除均无影响。在SRBC注射前6次给予10.0 mg/kg的DSG时，实验小鼠和对照小鼠的血凝滴度无显著差异。然而，在反应过程中（第0至5天）给予DSG（5.0 mg/kg/天）时，明显抑制了抗体形成。