Keller Tymen T, van Leuven Sander I, Meuwese Marijn C, Wareham Nicholas J, Luben Robert, Stroes Erik S, Hack C Erik, Levi Marcel, Khaw Kay-Tee, Boekholdt S Matthijs
Academic Medical Center of Amsterdam, Department of Vascular Medicine (Room F4-121), Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2345-50. doi: 10.1161/01.ATV.0000240517.69201.77. Epub 2006 Aug 10.
To determine the association between serum levels of mannose-binding lectin (MBL) and the risk of future coronary artery disease (CAD) in apparently healthy men and women.
We performed a prospective case-control study among apparently healthy men and women nested in the EPIC-Norfolk cohort. Baseline concentrations of MBL were measured in serum samples of 946 patients who experienced a myocardial infarction or died of CAD during follow-up, and 1799 matched controls who remained free of CAD. Among men, median MBL levels were 1.63 ng/mL (interquartile range [IQR]: 0.59 to 3.80) in cases and 1.20 ng/mL (IQR: 0.48 to 3.37) in controls. Among women, median MBL levels were 1.02 ng/mL (IQR: 0.43 to 2.95) in cases and 1.01 ng/mL (IQR: 0.43 to 2.94) in controls. After adjustment, the odds ratio in men for future CAD was 1.59 (95% confidence interval [CI]: 1.09 to 2.32; P for linearity=0.01) for those in the highest quartile compared with those in the lowest quartile. In women no such relation was observed.
Elevated levels of MBL are associated with an increased risk of future CAD in apparently healthy men but not in women. The sex difference merits further exploration.
确定在看似健康的男性和女性中，血清甘露糖结合凝集素（MBL）水平与未来患冠状动脉疾病（CAD）风险之间的关联。
我们在EPIC-诺福克队列中纳入的看似健康的男性和女性中进行了一项前瞻性病例对照研究。在随访期间发生心肌梗死或死于CAD的946例患者以及1799例未患CAD的匹配对照的血清样本中测量了MBL的基线浓度。在男性中，病例组MBL水平中位数为1.63 ng/mL（四分位间距[IQR]：0.59至3.80），对照组为1.20 ng/mL（IQR：0.48至3.37）。在女性中，病例组MBL水平中位数为1.02 ng/mL（IQR：0.43至2.95），对照组为1.01 ng/mL（IQR：0.43至2.94）。调整后，与最低四分位数组相比，最高四分位数组男性未来患CAD的优势比为1.59（95%置信区间[CI]：1.09至2.32；线性P值 = 0.01）。在女性中未观察到这种关系。
在看似健康的男性中，MBL水平升高与未来患CAD的风险增加相关，但在女性中并非如此。这种性别差异值得进一步探究。
