Laboratory of Molecular Immunopathology, Clinical Hospital, Federal University of Paraná (HC-UFPR), Curitiba, Brazil.
Department of Medicine, Positivo University, Curitiba, Brazil.
Immunol Invest. 2024 Jul;53(5):752-765. doi: 10.1080/08820139.2024.2337023. Epub 2024 Apr 18.
The process of tissue injury in coronary artery disease (CAD) has been associated with activation of the complement system, partly due to the action of mannose-binding lectin (MBL) and C3, which are expressed in atherosclerotic lesions.
The aim of this study was to evaluate the serum levels of MBL and C3 in patients with CAD and to compare them with healthy controls. Additionally, we aim to assess the correlation between MBL and C3 levels and cardiometabolic parameters.
MBL and C3 serum concentration were determined by ELISA and immunoturbidimetry, respectively, in up to 119 patients undergoing coronary angiography for CAD evaluation, comprising 48 individuals diagnosed with acute myocardial infarction (MI) and 71 without MI. A total of 93 paired healthy controls were included in the study.
Individuals with CAD had MBL serum concentration higher than controls ( = .002), regardless of the presence of MI ( = .006). In addition, high concentration of MBL (>2000 ng/mL) was more frequent in patients with CAD ( = .007; OR = 2.6; 95% CI = 1.3-5.1). C3 levels were not significantly associated with any of the patient groups but were positively correlated with cardiometabolic parameters such as body mass index (BMI) and triglycerides levels.
Higher concentrations of MBL were found to be associated with CAD, whereas C3 levels were found to be associated with cardiovascular risk factors.
冠状动脉疾病（CAD）的组织损伤过程与补体系统的激活有关，部分原因是甘露糖结合凝集素（MBL）和 C3 的作用，它们在动脉粥样硬化病变中表达。
本研究旨在评估 CAD 患者的 MBL 和 C3 血清水平，并将其与健康对照组进行比较。此外，我们旨在评估 MBL 和 C3 水平与心血管代谢参数之间的相关性。
通过 ELISA 和免疫比浊法分别测定 119 例接受冠状动脉造影评估 CAD 的患者和 93 例配对健康对照组的 MBL 和 C3 血清浓度，其中 48 例被诊断为急性心肌梗死（MI），71 例没有 MI。
CAD 患者的 MBL 血清浓度高于对照组（= 0.002），无论是否存在 MI（= 0.006）。此外，CAD 患者中 MBL 浓度较高（>2000 ng/mL）更为常见（= 0.007；OR = 2.6；95% CI = 1.3-5.1）。C3 水平与任何患者组均无显著相关性，但与心血管代谢危险因素如体重指数（BMI）和甘油三酯水平呈正相关。
较高的 MBL 浓度与 CAD 相关，而 C3 水平与心血管危险因素相关。
