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Analysis of Qa-2 antigen expression by preimplantation mouse embryos: possible relationship to the preimplantation-embryo-development (Ped) gene product.着床前小鼠胚胎Qa-2抗原表达分析：与着床前胚胎发育（Ped）基因产物的可能关系。
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The soluble pool of HLA-G produced by human trophoblasts does not include detectable levels of the intron 4-containing HLA-G5 and HLA-G6 isoforms.人滋养层细胞产生的可溶性HLA - G库中不包含可检测水平的含第4内含子的HLA - G5和HLA - G6同种型。
Mol Hum Reprod. 2005 Oct;11(10):699-710. doi: 10.1093/molehr/gah185. Epub 2005 Dec 5.
2
Does 'soluble' HLA-G really exist? Another twist to the tale.“可溶性” HLA-G真的存在吗？故事的又一转折。
Mol Hum Reprod. 2005 Oct;11(10):695-8. doi: 10.1093/molehr/gah196. Epub 2005 Dec 5.
3
HLA-G in human reproduction: aspects of genetics, function and pregnancy complications.人类生殖中的HLA-G：遗传学、功能及妊娠并发症方面
Hum Reprod Update. 2006 May-Jun;12(3):209-32. doi: 10.1093/humupd/dmi048. Epub 2005 Nov 9.
4
Soluble human leukocyte antigen G expression in phase I culture media at 46 hours after fertilization predicts pregnancy and implantation from day 3 embryo transfer.受精后46小时I期培养基中可溶性人类白细胞抗原G的表达可预测第3天胚胎移植后的妊娠和着床情况。
Fertil Steril. 2005 May;83(5):1410-3. doi: 10.1016/j.fertnstert.2004.11.061.
5
Genetics and imaging to assess oocyte and preimplantation embryo health.用于评估卵母细胞和植入前胚胎健康状况的遗传学与影像学检查
Reprod Fertil Dev. 2004;16(7):729-41. doi: 10.1071/rd04088.
6
Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface.HLA-G的晶体结构：一种在母胎界面表达的非经典MHC I类分子。
Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3360-5. doi: 10.1073/pnas.0409676102. Epub 2005 Feb 17.
7
Secretion of human leukocyte antigen-G by human embryos is associated with a higher in vitro fertilization pregnancy rate.人类胚胎分泌人白细胞抗原-G与体外受精妊娠率较高相关。
Fertil Steril. 2005 Jan;83(1):30-6. doi: 10.1016/j.fertnstert.2004.06.059.
8
Soluble HLA-G (sHLA-G) a predictor of IVF outcome?可溶性人类白细胞抗原G（sHLA-G）是体外受精结果的预测指标吗？
J Assist Reprod Genet. 2004 Sep;21(9):315-6. doi: 10.1023/b:jarg.0000045469.08910.1e.
9
Embryonic soluble HLA-G as a marker of developmental potential in embryos.胚胎可溶性人类白细胞抗原G作为胚胎发育潜能的标志物。
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10
Expression of sHLA-G in supernatants of individually cultured 46-h embryos: a potentially valuable indicator of 'embryo competency' and IVF outcome.单独培养46小时胚胎的上清液中可溶性人类白细胞抗原G（sHLA-G）的表达：“胚胎发育潜能”和体外受精结果的潜在重要指标
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对B6.K1和B6.K2 Ped基因同源小鼠植入前胚胎的性别比例分析。

Analysis of the sex ratio in preimplantation embryos from B6.K1 and B6.K2 Ped gene congenic mice.

作者信息

Byrne Michael J, Newmark Judith A, Warner Carol M

机构信息

Department of Biology, Northeastern University, 134 Mugar Hall, Boston, MA 02115, USA.

出版信息

J Assist Reprod Genet. 2006 Jul-Aug;23(7-8):321-8. doi: 10.1007/s10815-006-9046-0. Epub 2006 Aug 11.

DOI:10.1007/s10815-006-9046-0
PMID:16902830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2529474/
Abstract

PURPOSE

The mouse preimplantation embryo development (Ped) gene product, Qa-2, which is the homolog of human HLA-G, influences the rate of preimplantation embryonic development and overall reproductive success. The sex ratio in preimplantation embryos from Ped gene congenic mice was examined in order to determine whether embryo sex is a confounding factor in the control of the rate of preimplantation development.

METHODS

B6.K1 (Ped slow) and B6.K2 (Ped fast) congenic mice differ only in the absence (B6.K1) or presence (B6.K2) of the genes encoding Qa-2 protein. We analyzed the sex of B6.K1 (n=221) and B6.K2 (n=260) preimplantation embryos by using Real-Time PCR with primers specific for the X and Y chromosomes.

RESULTS

We found that there was no statistically significant difference in the ratio of male to female preimplantation embryos in either strain.

CONCLUSIONS

We conclude that the sex of the embryos is not a confounding factor that affects the Ped gene control of the rate of preimplantation development. Therefore, the Ped gene is entirely responsible for mediating the faster development of B6.K2 embryos compared to B6.K1 embryos.

摘要

目的

小鼠着床前胚胎发育（Ped）基因产物Qa-2是人类HLA-G的同源物，它影响着床前胚胎发育的速率和整体繁殖成功率。为了确定胚胎性别是否是着床前发育速率控制中的一个混杂因素，我们对Ped基因同源小鼠着床前胚胎的性别比例进行了检测。

方法

B6.K1（Ped慢）和B6.K2（Ped快）同源小鼠仅在编码Qa-2蛋白的基因的缺失（B6.K1）或存在（B6.K2）方面存在差异。我们使用针对X和Y染色体的特异性引物通过实时PCR分析了B6.K1（n = 221）和B6.K2（n = 260）着床前胚胎的性别。

结果

我们发现，在这两个品系中，着床前胚胎的雌雄比例均无统计学上的显著差异。

结论

我们得出结论，胚胎性别不是影响Ped基因对着床前发育速率控制的混杂因素。因此，与B6.K1胚胎相比，Ped基因完全负责介导B6.K2胚胎的更快发育。