Hviid Thomas Vauvert F
Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet.
Hum Reprod Update. 2006 May-Jun;12(3):209-32. doi: 10.1093/humupd/dmi048. Epub 2005 Nov 9.
The non-classical human leukocyte antigen (HLA) class Ib genes, HLA-E, -G and -F, are located on chromosome 6 in the human major histocompatibility complex (MHC). HLA class Ib antigens resemble the HLA class Ia antigens in many ways, but several major differences have been described. This review will, in particular, discuss HLA-G and its role in human reproduction and in the human MHC. HLA-G seems to be important in the modulation of the maternal immune system during pregnancy and thereby the maternal acceptance of the semiallogenic fetus. Recent findings regarding aspects of HLA-G polymorphism, the possible significance of this polymorphism in respect to HLA-G function and certain complications of pregnancy (such as pre-eclampsia and recurrent spontaneous abortions (RSA)) are discussed together with possible importance to IVF. Finally, aspects of a possible role of HLA-G in organ transplantation and in inflammatory or autoimmune disease, and of HLA-G in an evolutionary context, are also briefly examined.
非经典人类白细胞抗原（HLA）I b类基因，即HLA-E、-G和-F，位于人类主要组织相容性复合体（MHC）的第6号染色体上。HLA I b类抗原在许多方面类似于HLA I a类抗原，但也存在一些主要差异。本综述将特别讨论HLA-G及其在人类生殖和人类MHC中的作用。HLA-G似乎在孕期调节母体免疫系统以及母体对半同种异体胎儿的接纳过程中发挥重要作用。本文讨论了关于HLA-G多态性的最新研究结果，这种多态性在HLA-G功能方面的可能意义以及某些妊娠并发症（如先兆子痫和复发性自然流产（RSA）），同时还探讨了其对体外受精的可能重要性。最后，还简要研究了HLA-G在器官移植、炎症或自身免疫性疾病中的可能作用，以及HLA-G在进化背景下的情况。
