Mahabusarakam Wilawan, Kuaha Kunnika, Wilairat Prapon, Taylor Walter C
Department of Chemistry, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Planta Med. 2006 Aug;72(10):912-6. doi: 10.1055/s-2006-947190. Epub 2006 Aug 10.
Mangostin, the major xanthone of Garcinia mangostana, and a series of synthetic derivatives were investigated for their in vitro antiplasmodial activity against Plasmodium falciparum. Mangostin itself showed moderate activity, but prenylated xanthones containing alkylamino functional groups exhibited quite potent antiplasmodial activity. Some structure-activity relationships are proposed.
山竹黄酮是藤黄属植物山竹果中的主要氧杂蒽酮，对一系列合成衍生物针对恶性疟原虫的体外抗疟活性进行了研究。山竹黄酮本身显示出中等活性，但含有烷基氨基官能团的异戊烯基氧杂蒽酮表现出相当强的抗疟活性。提出了一些构效关系。
