Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Knowledge park-III, Greater Noida, 201310, U.P.), India.
Center of Medical Biotechnology, Maharishi Dayanand University, Rohtak, Haryana, 124001, India.
Appl Biochem Biotechnol. 2022 Oct;194(10):4724-4744. doi: 10.1007/s12010-022-04031-2. Epub 2022 Jul 19.
The Garcinia mangostana Linn (Mangosteen) is also called as "Queen of Fruits" in Malaysia. It is found in the region of Southeast Asia. It is a medicinal plant that has been used to treat cancer in a variety of cell lines. The mangosteen pericarp possesses distinctive biological properties like anticancer or antitumoral and antioxidant. It has a distinct sweet and sour taste, rich in biological compounds like xanthones. It exhibits various properties like apoptotic in tumor cells which leads to the suppression of their growth and results in their various sizes. The primary purpose of this review article is to summarize the valuable results covered by the researchers so far in the Garcinia mangostana extract and its compound like xanthones. Our focus was to explain the role of the phytoconstituent molecules in invading the cancer pathways to combat the expansion of cells. Furthermore, we still feel that there is a scope for more in silico and in vivo studies to understand and identify the specific site of action in tumoral cells and their mechanistic pathways. In conclusion, Garcinia mangostana can act as an anticancer agent by attacking various molecular pathways.
藤黄科藤黄属植物（山竹）在马来西亚也被称为“水果皇后”。它分布于东南亚地区。它是一种药用植物，已被用于治疗多种细胞系的癌症。山竹果皮具有独特的生物特性，如抗癌或抗肿瘤和抗氧化。它具有独特的酸甜味道，富含生物化合物如黄烷酮。它表现出各种特性，如肿瘤细胞中的凋亡，导致其生长受到抑制，从而导致其大小不同。本文综述的主要目的是总结迄今为止研究人员在藤黄提取物及其化合物如黄烷酮方面所取得的有价值的结果。我们的重点是解释植物化学成分分子在入侵癌症途径以对抗细胞扩张方面的作用。此外，我们仍然认为，需要进行更多的计算机模拟和体内研究，以了解和确定肿瘤细胞中特定的作用位点及其机制途径。总之，藤黄可以通过攻击各种分子途径来作为一种抗癌剂。
