芽孢孢菌素D和E，来自芽孢孢菌的新型氧化苯并菲二聚体。
Bacillisporins D and E, new oxyphenalenone dimers from Talaromyces bacillisporus.
作者信息
Dethoup Tida, Manoch Leka, Kijjoa Anake, Nascimento Maria São, Puaparoj Prapawadee, Silva Artur M, Eaton Graham, Herz Werner
机构信息
Department of Plant Pathology, Faculty of Agriculture, Kasetsart University, Bangkok, Thailand.
出版信息
Planta Med. 2006 Aug;72(10):957-60. doi: 10.1055/s-2006-947188. Epub 2006 Aug 10.
The oligophenalenone dimer duclauxin and two new analogues, bacillisporins D and E, were isolated from the fungus TALAROMYCES BACILLISPORUS in addition to the previously reported bacillisporins A, B and C. Structures were established by spectroscopic studies. Duclauxin and bacillisporins A, B, C and E were evaluated for cytotoxicity against three human cancer cell lines. Bacillisporin A was strongly active against MCF-7 and NCI-H460 and moderately active against SF-268 while bacillisporins B, C and duclauxin were moderately active against all three cell lines.
除了先前报道的杆菌孢菌素A、B和C外，从塔宾曲霉中分离出了寡菲并萘酮二聚体杜克拉霉素以及两种新的类似物杆菌孢菌素D和E。通过光谱研究确定了它们的结构。对杜克拉霉素以及杆菌孢菌素A、B、C和E进行了针对三种人类癌细胞系的细胞毒性评估。杆菌孢菌素A对MCF-7和NCI-H460具有强活性，对SF-268具有中等活性，而杆菌孢菌素B、C和杜克拉霉素对所有三种细胞系均具有中等活性。
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