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来源于青霉菌株JP-1的聚酮化合物，JP-1是一种与红树植物桐花树相关的内生真菌。

Polyketides from Penicillium sp. JP-1, an endophytic fungus associated with the mangrove plant Aegiceras corniculatum.

作者信息

Lin Zhenjian, Zhu Tianjiao, Fang Yuchun, Gu Qianqun, Zhu Weiming

机构信息

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China.

出版信息

Phytochemistry. 2008 Mar;69(5):1273-8. doi: 10.1016/j.phytochem.2007.10.030. Epub 2007 Dec 11.

DOI:10.1016/j.phytochem.2007.10.030
PMID:18067932
Abstract

Four polyketides, leptosphaerone C (1), penicillenone (2), arugosin I (3) and 9-demethyl FR-901235 (4), as well as five known compounds, bacillosporin A (5), bacillosporin C (6), sequoiamonascin D (7), sequoiatone A (8), and sequoiatone B (9) were isolated from the Penicillium sp. JP-1, an endophytic fungus isolated from Aegiceras corniculatum. Their structures were determined by spectroscopic methods, mainly by 2D NMR spectroscopic analyses. Compound 1 showed cytotoxicity against A-549 cells with an IC50 value of 1.45 microM, while compound 2 showed cytotoxicity against P388 cells with an IC50 value of 1.38 microM.

摘要

从红树桐花树内生真菌青霉属JP-1中分离得到4种聚酮化合物，即细交链孢菌酮C（1）、青霉烯酮（2）、rugosin I（3）和9-去甲基FR-901235（4），以及5种已知化合物，即芽孢杆菌素A（5）、芽孢杆菌素C（6）、红杉霉素D（7）、红杉酮A（8）和红杉酮B（9）。它们的结构通过光谱方法确定，主要是二维核磁共振光谱分析。化合物1对A-549细胞显示出细胞毒性，IC50值为1.45微摩尔，而化合物2对P388细胞显示出细胞毒性，IC50值为1.38微摩尔。

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