Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming 650091, People's Republic of China.
J Nat Prod. 2011 Oct 28;74(10):2278-81. doi: 10.1021/np200365z. Epub 2011 Oct 3.
Six indole alkaloids with various levels of prenylation were isolated from the thermophilic fungus Talaromyces thermophilus strain YM3-4. Their structures were identified by NMR and MS spectroscopic analyses. Compounds 1 and 2 are new analogues of the key versatile precursor notoamide E. Compound 3 is a novel analogue of preechinulin, and compound 4 was reported as a natural occurring cyclo(glycyltryptophyl) for the first time. The metabolite profile of this thermophilic organism displayed a biosynthetic pathway for talathermophilins.
从嗜热真菌塔玛亚历山大菌 YM3-4 中分离得到了 6 种具有不同程度 prenylation 的吲哚生物碱。通过 NMR 和 MS 光谱分析鉴定了它们的结构。化合物 1 和 2 是关键多功能前体 notoamide E 的新类似物。化合物 3 是 preechinulin 的新型类似物，化合物 4 是首次报道的天然存在的环（甘氨酰色氨酰）。这种嗜热生物的代谢产物谱显示了 talathermophilins 的生物合成途径。
