Modica Salvatore, Moschetta Antonio
Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale 8A, Santa Maria Imbaro Chieti, CH, Chieti 66030, Italy.
FEBS Lett. 2006 Oct 9;580(23):5492-9. doi: 10.1016/j.febslet.2006.07.082. Epub 2006 Aug 8.
The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that is primarily expressed in the enterohepatic system where it functions as intracellular sensor for bile acids. Ligand dependent FXR activation induces transcriptional responses to coordinately regulate bile acid, cholesterol, triglyceride and glucose metabolism, and to protect the intestinal mucosa from bacterial overgrowth and inflammatory insults. Here we discuss the latest discoveries in FXR-driven metabolic pathways with relevance to pathophysiology and novel therapeutic approaches of several conditions such as hypertriglyceridemia, type 2 diabetes, cholesterol gallstone disease, steato-hepatitis and metabolic syndrome.
法尼醇X受体（FXR）是核受体超家族的成员，主要在肠肝系统中表达，在该系统中它作为胆汁酸的细胞内传感器发挥作用。配体依赖性FXR激活诱导转录反应，以协调调节胆汁酸、胆固醇、甘油三酯和葡萄糖代谢，并保护肠黏膜免受细菌过度生长和炎症损伤。在此，我们讨论FXR驱动的代谢途径的最新发现，这些发现与几种疾病（如高甘油三酯血症、2型糖尿病、胆固醇结石病、脂肪性肝炎和代谢综合征）的病理生理学和新型治疗方法相关。
