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高脂饮食诱导的高脂血症C57BL/6J小鼠中，变种提取的多糖的降血脂和保肝作用

Hypolipidemic and Hepatoprotective Effects of Polysaccharides Extracted from Var. in C57BL/6J Mice with High-Fat Diet-Induced Hyperlipidemia.

作者信息

Liu Yi-Hui, Xiang Zhi-Nan, Chen Chen, Wan Luo-Sheng, Chen Jia-Chun

机构信息

Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmacy Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.

出版信息

Evid Based Complement Alternat Med. 2020 Dec 10;2020:8013189. doi: 10.1155/2020/8013189. eCollection 2020.

DOI:10.1155/2020/8013189
PMID:33376498
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7746456/
Abstract

In this study, C57BL/6J mice with high-fat diet- (HFD-) induced hyperlipidemia were treated with total var. polysaccharides (TLSP: 200, 400, and 800 mg/kg body weight), simvastatin (3 mg/kg body weight), or saline for 8 weeks, respectively. The results showed that TLSP had strong lipid-lowering and hepatoprotective effects on C57BL/6J mice with HFD-induced hyperlipidemia. TLSP administration significantly reduced serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels and downregulated the expressions of peroxisome proliferator-activated receptor (PPAR) and fatty acid synthase (FAS) in the adipose and liver tissues of the mice. TLSP exerted hypolipidemic and hepatoprotective effects by activating lipid/bile acid metabolism via the FXH-SHP/CYP7A1 and SEBP-1c/FAC/ACC signaling pathways. Thus, TLPS is a promising natural polymer with hepatoprotective and hypolipidemic properties.

摘要

在本研究中，将高脂饮食（HFD）诱导的高脂血症C57BL/6J小鼠分别用总变种多糖（TLSP：200、400和800毫克/千克体重）、辛伐他汀（3毫克/千克体重）或生理盐水处理8周。结果表明，TLSP对HFD诱导的高脂血症C57BL/6J小鼠具有强大的降脂和保肝作用。给予TLSP可显著降低小鼠血清总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）水平，并下调小鼠脂肪和肝脏组织中过氧化物酶体增殖物激活受体（PPAR）和脂肪酸合酶（FAS）的表达。TLSP通过FXH-SHP/CYP7A1和SEBP-1c/FAC/ACC信号通路激活脂质/胆汁酸代谢，发挥降脂和保肝作用。因此，TLPS是一种具有保肝和降脂特性的有前途的天然聚合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31d9/7746456/00c50479c985/ECAM2020-8013189.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31d9/7746456/190b187ad76f/ECAM2020-8013189.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31d9/7746456/809ae687ebae/ECAM2020-8013189.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31d9/7746456/4399a5ddd567/ECAM2020-8013189.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31d9/7746456/28443390936e/ECAM2020-8013189.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31d9/7746456/82eaefde70bf/ECAM2020-8013189.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31d9/7746456/9b9e53b39056/ECAM2020-8013189.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31d9/7746456/00c50479c985/ECAM2020-8013189.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31d9/7746456/190b187ad76f/ECAM2020-8013189.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31d9/7746456/809ae687ebae/ECAM2020-8013189.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31d9/7746456/4399a5ddd567/ECAM2020-8013189.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31d9/7746456/28443390936e/ECAM2020-8013189.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31d9/7746456/82eaefde70bf/ECAM2020-8013189.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31d9/7746456/9b9e53b39056/ECAM2020-8013189.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31d9/7746456/00c50479c985/ECAM2020-8013189.007.jpg

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