CD16+/CD56-/2B4+自然杀伤细胞的持续存在：一种在眼肌型重症肌无力中扩增的高度功能失调的自然杀伤细胞亚群。

Persistence of CD16+/CD56-/2B4+ natural killer cells: a highly dysfunctional NK subset expanded in ocular myasthenia gravis.

作者信息

Nguyen Stéphanie, Morel Véronique, Le Garff-Tavernier Magali, Bolgert Francis, Leblond Véronique, Debré Patrice, Vieillard Vincent

机构信息

INSERM U543, Laboratoire d'Immunologie Cellulaire et Tissulaire, Hôpital Pitié-Salpêtrière, Paris, France.

出版信息

J Neuroimmunol. 2006 Oct;179(1-2):117-25. doi: 10.1016/j.jneuroim.2006.05.028. Epub 2006 Aug 14.

DOI:10.1016/j.jneuroim.2006.05.028

PMID:16904757

Abstract

We report a case of myasthenia gravis associated with marked expansion of an unusual CD16(+)CD56(-)2B4(+) NK subset. These atypical cells were characterized by poor cytotoxicity against CD48(+) target cells and high proliferation due to 2B4/CD48 interaction. IL18, IFN-gamma and TGF-beta levels were profoundly different in this patient than in healthy donors. Immunosuppressive treatment induced disease remission and decreased the CD16(+)CD56(-)2B4(+)NK cells count. Our data suggest that expansion of this NK subset in myasthenia gravis patients may account for the deleterious NK cell functioning that occurs in this autoimmune disease.

摘要

我们报告了一例重症肌无力病例，该病例伴有一种不寻常的 CD16(+)CD56(-)2B4(+)自然杀伤细胞亚群显著扩增。这些非典型细胞的特征是对 CD48(+)靶细胞的细胞毒性较差，且由于 2B4/CD48 相互作用而具有高增殖性。该患者的白细胞介素 18、干扰素 -γ 和转化生长因子 -β 水平与健康供体相比有很大差异。免疫抑制治疗诱导疾病缓解并降低了 CD16(+)CD56(-)2B4(+)自然杀伤细胞计数。我们的数据表明，重症肌无力患者中这种自然杀伤细胞亚群的扩增可能是导致该自身免疫性疾病中自然杀伤细胞功能有害的原因。