Youinou P, Mackenzie L, Katsikis P, Merdrignac G, Isenberg D A, Tuaillon N, Lamour A, Le Goff P, Jouquan J, Drogou A
Laboratory of Immunology, Brest University Medical School, France.
Arthritis Rheum. 1990 Mar;33(3):339-48. doi: 10.1002/art.1780330306.
The influence of genetic factors on the expression of CD5+ B lymphocytes and their relationship to a broad spectrum of autoantibodies was investigated in a study of 12 patients with rheumatoid arthritis (RA) and 52 of their healthy first-degree relatives. The proportion of CD5+ B cells was significantly higher in RA patients (mean +/- SEM 23.9 +/- 2.7%) compared with that in their relatives (18.3 +/- 1.1%, P less than 0.05) and compared with that in a group of healthy control subjects (16.1 +/- 1.8%; P less than 0.05). Much more striking, however, were the high levels of CD5+ B cells found in the patients and their relatives in 5 of the families studied. Increases in total immunoglobulin levels and autoantibody levels were frequently observed in RA patients (approximately 20-40%) and their relatives (approximately 10-20%). Furthermore, a statistically significant correlation (P less than 0.01) between IgM rheumatoid factor and the percentage of B lymphocytes expressing CD5 was observed.
在一项针对12名类风湿性关节炎（RA）患者及其52名健康的一级亲属的研究中，调查了遗传因素对CD5⁺ B淋巴细胞表达的影响及其与多种自身抗体的关系。与亲属（18.3±1.1%，P<0.05）及一组健康对照者（16.1±1.8%；P<0.05）相比，RA患者中CD5⁺ B细胞的比例显著更高（平均±标准误为23.9±2.7%）。然而，在所研究的5个家庭的患者及其亲属中发现的高水平CD5⁺ B细胞更为显著。在RA患者（约20 - 40%）及其亲属（约10 - 20%）中经常观察到总免疫球蛋白水平和自身抗体水平升高。此外，观察到IgM类风湿因子与表达CD5的B淋巴细胞百分比之间存在统计学显著相关性（P<0.01）。
