Hara M, Kitani A, Hirose T, Norioka K, Harigai M, Suzuki K, Tabata H, Kawakami M, Kawagoe M, Nakamura H
First Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Clin Immunol Immunopathol. 1988 Nov;49(2):223-30. doi: 10.1016/0090-1229(88)90112-2.
In order to clarify the role of CD5 antigen on B cell in autoimmunity, we examined B cells from patients with rheumatoid arthritis (RA). The percentages of CD5 positive B cells were increased in peripheral blood from RA compared with normal. Normal and RA B cells were stimulated with two kinds of monoclonal antibodies to CD5 (Leu-1, SL-1) which recognize different epitopes. RA B cells proliferated and secreted IgM by CD5 antibody stimulation in combination with IL-1. Our observations imply that CD5 positive B cells in RA are in their differentiation stage and that CD5 antigen might be one of the triggers to activate CD5 positive B cells in vivo to produce autoantibody.
为了阐明B细胞上CD5抗原在自身免疫中的作用，我们检测了类风湿关节炎（RA）患者的B细胞。与正常人相比，RA患者外周血中CD5阳性B细胞的百分比增加。用两种识别不同表位的抗CD5单克隆抗体（Leu-1、SL-1）刺激正常和RA的B细胞。RA的B细胞在CD5抗体刺激并联合IL-1的情况下增殖并分泌IgM。我们的观察结果提示，RA中CD5阳性B细胞处于分化阶段，并且CD5抗原可能是体内激活CD5阳性B细胞以产生自身抗体的触发因素之一。
