Suppr超能文献

[有选择性指征的小肾肿瘤保留肾单位手术的长期结果]

[Long-term results of nephron-sparing surgery for small renal tumors with elective indications].

作者信息

Pertiia A R, Managadze L G

出版信息

Georgian Med News. 2006 Jun(135):12-6.

Abstract

The widespread use of modern radiological techniques substantially changed clinical presentation of renal cell carcinoma (RCC) in the recent decades. Currently, more than one half of all patients with surgically resectable renal tumors are detected incidentally. In this due interest in nephron sparing surgery (NSS) for the treatment of small localized tumors has increased. The amount of healthy parenchyma that should be removed together with the tumor to minimize the risk of local recurrence is an important and controversial issue. In the present study we retrospectively studied 44 cases of NSS performed for elective indications. A total of 44 patients underwent elective NSS from 1994 to 2001. According to the operative techniques the patients were distributed in two groups. Group I consisted of 17 patients who underwent "enucleoresection" with a small part of normal parenchyma around the excised tumors. The rest 27 patients (Group II) underwent NSS by means of enucleation. Mean follow-up was 88.36+/-24.75 months (range: 49-146 months). The mean tumor size was 37,04+/-4,65 cc (range: 25 to 45). There was no perioperative mortality. Hemorrhage was observed in 1 patient (5,9%) from Group I. Urinary leakage was observed in 3 (6,8%) cases in both groups: two (11,7%) in group I and one (3,7%) in group II. No local recurrence was observed during the follow-up period. One patient (2, 8%) developed distant metastases and died at 81 month postoperatively. 5-year cancer specific survival was 97,6 %. Simple tumor enucleation is a safe and acceptable approach for elective NSS. It provides excellent long-term progression-free and cancer specific survival rates, and is not associated with an increased risk of local recurrence compared with partial nephrectomy.

摘要

近几十年来,现代放射技术的广泛应用极大地改变了肾细胞癌(RCC)的临床表现。目前,超过一半的可手术切除肾肿瘤患者是偶然发现的。因此,对保留肾单位手术(NSS)治疗小的局限性肿瘤的兴趣增加。为将局部复发风险降至最低,应与肿瘤一并切除的健康实质组织量是一个重要且有争议的问题。在本研究中,我们回顾性研究了44例因选择性指征而行NSS的病例。1994年至2001年,共有44例患者接受了选择性NSS。根据手术技术,患者分为两组。第一组由17例患者组成,他们接受了“剜除切除术”,切除肿瘤周围一小部分正常实质组织。其余27例患者(第二组)通过剜除术接受了NSS。平均随访时间为88.36±24.75个月(范围:49 - 146个月)。平均肿瘤大小为37.04±4.65立方厘米(范围:25至45)。无围手术期死亡。第一组有1例患者(5.9%)出现出血。两组均有3例(6.8%)出现尿漏:第一组2例(11.7%),第二组1例(3.7%)。随访期间未观察到局部复发。1例患者(2.8%)发生远处转移,术后81个月死亡。5年癌症特异性生存率为97.6%。单纯肿瘤剜除术是选择性NSS的一种安全且可接受的方法。它提供了优异的长期无进展生存率和癌症特异性生存率,与部分肾切除术相比,局部复发风险并未增加。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验