Spiess Philippe E, Grossman H Barton
Department of Urology, University of Texas, M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
Curr Opin Urol. 2006 Sep;16(5):372-6. doi: 10.1097/01.mou.0000240312.16324.9a.
To review the recent literature on the use of fluorescence cystoscopy in the diagnosis and management of bladder cancer.
Recent advances have been made in fluorescence cystoscopy with the use of newer fluorescence agents (hexylester aminolevulinate and hypericin) and their application to flexible cystoscopy. Within several hours of intravesical administration of these agents, bladder tumors can be detected using fluorescence cystoscopy resulting in improved cancer detection and lower short-term recurrence rates than white light cystoscopy. Preliminary results with flexible fluorescence cystoscopy suggest that this technique can be used for office-based cystoscopy.
Significant advances have been made in the field of fluorescence cystoscopy. The currently available fluorescence agents in recent phase II and III trials outperform white light cystoscopy in terms of cancer detection and recurrence-free survival. Fluorescence cystoscopy should be considered as an adjunctive tool for the diagnosis and management of superficial bladder cancer.
回顾近期关于荧光膀胱镜在膀胱癌诊断和治疗中应用的文献。
荧光膀胱镜在使用新型荧光剂（己酯氨基乙酰丙酸和金丝桃素）及其在软性膀胱镜检查中的应用方面取得了进展。在膀胱内给予这些药剂后的数小时内，使用荧光膀胱镜可检测出膀胱肿瘤，与白光膀胱镜相比，癌症检测率提高且短期复发率降低。软性荧光膀胱镜的初步结果表明，该技术可用于门诊膀胱镜检查。
荧光膀胱镜领域取得了重大进展。近期II期和III期试验中现有的荧光剂在癌症检测和无复发生存方面优于白光膀胱镜。荧光膀胱镜应被视为浅表性膀胱癌诊断和治疗的辅助工具。
