Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1088, USA.
Future Oncol. 2009 Nov;5(9):1501-11. doi: 10.2217/fon.09.109.
Near-infrared (NIR) fluorescence cancer imaging is a growing field for both preclinical and clinical application to the clinical management for cancer patients due to its advantageous features, including a high spatial resolution, portability, real-time display and detailed molecular profiling with the multiplexed use of fluorescent probes. In this review, we present a basic concept of NIR fluorescence imaging and overview its potential clinical applications for in vivo cancer imaging, including cancer detection/characterization, lymphatic imaging (sentinel lymph node detection) and surgical/endoscopic guidance. NIR fluorescence imaging can compensate some limitations of conventional imaging modalities, and thus it could play an important role for cancer imaging combined with other modalities in clinical practice.
近红外（NIR）荧光癌症成像技术在临床管理癌症患者方面的应用具有较高的空间分辨率、便携性、实时显示和详细的分子分析等优势，是一个在临床前和临床应用中都在不断发展的领域。在本文中，我们介绍了 NIR 荧光成像的基本概念，并概述了其在体内癌症成像中的潜在临床应用，包括癌症检测/特征描述、淋巴成像（前哨淋巴结检测）和手术/内镜引导。NIR 荧光成像可以弥补传统成像方式的一些局限性，因此它可能在与其他方式相结合的癌症成像中发挥重要作用。
