寻找烯炔复分解反应中反应活性和选择性问题的解决方案。

Search for solutions to the reactivity and selectivity problems in enyne metathesis.

作者信息

Hansen Eric C, Lee Daesung

机构信息

Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

出版信息

Acc Chem Res. 2006 Aug;39(8):509-19. doi: 10.1021/ar050024g.

DOI:10.1021/ar050024g

PMID:16906747

Abstract

Enyne metathesis is a powerful carbon-carbon bond-forming reaction to generate 1,3-dienes from an alkyne and an alkene. Different from the diene and diyne metathesis, the enyne metathesis suffers from both regio- and stereoselectivity problems, yet there is no general solution to these problems. This Account briefly describes the evolution of various new strategies and substrate platforms from these laboratories to address the reactivity and selectivity issues in the enyne metathesis processes.

摘要

烯炔复分解反应是一种强大的碳-碳键形成反应，可由炔烃和烯烃生成1,3-二烯。与二烯和二炔复分解反应不同，烯炔复分解反应存在区域选择性和立体选择性问题，然而这些问题尚无通用的解决方法。本综述简要介绍了来自这些实验室的各种新策略和底物平台的发展历程，以解决烯炔复分解反应过程中的反应活性和选择性问题。