Miró Javier, Sánchez-Roselló María, Sanz Álvaro, Rabasa Fernando, Del Pozo Carlos, Fustero Santos
Departamento de Química Orgánica, Universidad de Valencia, E-46100 Burjassot, Spain.
Departamento de Química Orgánica, Universidad de Valencia, E-46100 Burjassot, Spain ; Laboratorio de Moléculas Orgánicas, Centro de Investigación Príncipe Felipe, E-46012 Valencia, Spain.
Beilstein J Org Chem. 2015 Aug 25;11:1486-93. doi: 10.3762/bjoc.11.161. eCollection 2015.
A new tandem cross enyne metathesis (CEYM)-intramolecular Diels-Alder reaction (IMDAR) has been carried out. It involves conjugated ketones, esters or amides bearing a remote olefin and aromatic alkynes as the starting materials. The overall process enables the preparation of a small family of linear bicyclic scaffolds in a very simple manner with moderate to good levels of diastereoselectivity. This methodology constitutes one of the few examples that employ olefins differently than ethylene in tandem CEYM-IMDAR protocols.
已经进行了一种新的串联交叉烯炔复分解反应（CEYM）-分子内狄尔斯-阿尔德反应（IMDAR）。该反应以带有远程烯烃的共轭酮、酯或酰胺以及芳族炔烃作为起始原料。整个过程能够以非常简单的方式制备一小类线性双环骨架，具有中等至良好的非对映选择性水平。这种方法是串联CEYM-IMDAR方案中少数几个使用不同于乙烯的烯烃的例子之一。
