Berezhkovskii Alexander M, Hummer Gerhard, Bezrukov Sergey M
Mathematical and Statistical Computing Laboratory, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, Maryland 20892, USA.
Phys Rev Lett. 2006 Jul 14;97(2):020601. doi: 10.1103/PhysRevLett.97.020601. Epub 2006 Jul 11.
We study the distribution of direct translocation times for particles passing through membrane channels connecting two reservoirs. The direct translocation time is a conditional first-passage time defined as the residence time of the particle in the channel while passing to the other side of the membrane directly, i.e., without returning to the reservoir from which it entered. We show that the distributions of direct translocation times are identical for translocation in both directions, independent of any asymmetry in the potential across the channel and, hence, the translocation probabilities.
我们研究了粒子通过连接两个储液器的膜通道时直接转运时间的分布。直接转运时间是一个条件首次通过时间，定义为粒子在直接穿过膜到达另一侧时在通道中的停留时间，即不返回其进入的储液器。我们表明，两个方向上的直接转运时间分布是相同的，与通道两端电势的任何不对称性无关，因此也与转运概率无关。
