Vaquero J, Coca S, Magallón R, Pontón P, Martinez R
Department of Neurosurgery, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
J Neurosurg. 1990 Apr;72(4):616-8. doi: 10.3171/jns.1990.72.4.0616.
A monoclonal antibody against the surface marker IOT-10 of natural killer (NK) cells was used to investigate the presence and distribution of these cells in a series of nine primary intracranial germinomas. In all of these tumors, IOT-10-positive NK cells were found in small numbers, mainly distributed among the tumor cells. The data obtained in the present study suggest that the presence of NK cells in primary intracranial germinomas can be influenced by factors other than the mere quantity of tumor-infiltrating lymphocytes.
一种针对自然杀伤（NK）细胞表面标志物IOT-10的单克隆抗体被用于研究这一系列9例原发性颅内生殖细胞瘤中这些细胞的存在及分布情况。在所有这些肿瘤中，均发现少量IOT-10阳性NK细胞，主要分布于肿瘤细胞之间。本研究获得的数据表明，原发性颅内生殖细胞瘤中NK细胞的存在可能受肿瘤浸润淋巴细胞数量以外的其他因素影响。
