Farzaneh F, Roberts Sa, Mandal D, Ollier B, Winters U, Kitchener H C, Brabin L
Academic Unit of Obstetrics & Gynaecology, St Mary's Hospital, Manchester, UK.
BJOG. 2006 Aug;113(8):961-4. doi: 10.1111/j.1471-0528.2006.00956.x.
The role of cytokines in protecting against human papillomavirus (HPV) and HPV-associated disease is not fully understood. We compared the frequency of the interleukin (IL)-10 polymorphism (G allele) at position --1082 and the distribution of GG/GA/AA genotypes among 116 HPV-positive women, grouped according to their cervical cytological profiles, with 119 HPV-negative controls with normal smears. No difference was observed in genotype frequency between the groups. Among women in the HPV-positive, smear-normal group, who were re-tested for HPV after 12 months, there was a significant inverse association between presence of at least one variant G allele (high activity) and HPV persistence (OR per G allele = 0.082 [95% CI 0.009-0.73], P= 0.001; after controlling for ethnicity). This association remained significant after controlling for age, smoking and hormonal contraception (OR = 0.028 [95% CI 0.001-0.66], P= 0.001). This preliminary study suggests that higher levels of IL-10 may prevent cervical neoplasia through their role in eliminating HPV.
细胞因子在预防人乳头瘤病毒（HPV）及HPV相关疾病中的作用尚未完全明确。我们比较了116名HPV阳性女性（根据宫颈细胞学特征分组）和119名涂片正常的HPV阴性对照者中白细胞介素（IL）-10基因-1082位点多态性（G等位基因）的频率以及GG/GA/AA基因型的分布情况。两组间基因型频率未观察到差异。在HPV阳性且涂片正常组的女性中，12个月后再次检测HPV，至少存在一个变异G等位基因（高活性）与HPV持续感染之间存在显著的负相关（每个G等位基因的比值比=0.082 [95%置信区间0.009 - 0.73]，P = 0.001；校正种族因素后）。校正年龄、吸烟和激素避孕因素后，这种关联仍然显著（比值比=0.028 [95%置信区间0.001 - 0.66]，P = 0.001）。这项初步研究表明，较高水平的IL-10可能通过其在清除HPV中的作用预防宫颈肿瘤形成。
