Bersani-Amado C A, Duarte A J, Tanji M M, Cianga M, Jancar S
Departamento de Immunologia, Universidade de São Paulo, Brasil.
J Rheumatol. 1990 Feb;17(2):153-8.
The subpopulations of lymphocytes (W3/25+ and OX8+) in the blood, spleen and lymph nodes were analyzed comparatively in rats susceptible (Holtzman) and resistant (Buffalo) to the development of adjuvant induced arthritis (AIA). In naive rats, it was found that the ratio (T helper/T suppressor) was significantly higher in Holtzman compared to Buffalo rats suggesting that the susceptible rats possess less suppressor cells than the resistant. Following induction of AIA (7 and 14 days) the ratio T helper/T suppressor was not significantly different in either strain. When the resistant strain was treated with 25 mg/kg of cyclophosphamide, the T suppressor cells were significantly reduced and this was followed by a strong potentiation of the AIA. Our data suggest that susceptibility to AIA is related to alterations in the T suppressor cell subset.
对易患（霍尔兹曼大鼠）和不易患（布法罗大鼠）佐剂诱导性关节炎（AIA）的大鼠的血液、脾脏和淋巴结中的淋巴细胞亚群（W3/25+和OX8+）进行了比较分析。在未致敏的大鼠中，发现霍尔兹曼大鼠的（辅助性T细胞/抑制性T细胞）比值显著高于布法罗大鼠，这表明易感大鼠的抑制性细胞比抗性大鼠少。诱导AIA后（7天和14天），两种品系的辅助性T细胞/抑制性T细胞比值均无显著差异。当抗性品系用25mg/kg环磷酰胺处理时，抑制性T细胞显著减少，随后AIA强烈增强。我们的数据表明，对AIA的易感性与抑制性T细胞亚群的改变有关。
