Littman A J, Vitiello M V, Foster-Schubert K, Ulrich C M, Tworoger S S, Potter J D, Weigle D S, McTiernan A
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.
Int J Obes (Lond). 2007 Mar;31(3):466-75. doi: 10.1038/sj.ijo.0803438. Epub 2006 Aug 15.
To investigate cross-sectional and longitudinal relationships among exercise, sleep, ghrelin and leptin.
We randomly assigned 173 post-menopausal sedentary overweight (body mass index >or=24.0 kg/m(2) and >33% body fat) women aged 50-75 years living in western Washington State to either a facility- and home-based moderate-intensity physical activity intervention or a stretching control group. Fasting plasma ghrelin, leptin, measured height, weight and self-reported sleep were assessed at baseline and 12 months.
There were no consistent cross-sectional patterns between self-reported sleep measures and ghrelin or leptin at baseline. The weight loss differences between exercisers and stretchers were greater for those who slept less at follow-up than at baseline compared to those whose sleep duration did not change (-3.2 kg, 95% confidence interval (CI) -5.8, -0.5). Improvements in sleep quality were associated with significantly greater differences between exercisers and stretchers for ghrelin increases (improved vs same sleep quality: +115 pg/ml, 95% CI +25, +206) and leptin decreases (improved vs worsened sleep quality: -5.7 ng/ml, 95% CI -9.5, -1.5).
There was only limited evidence that changes in sleep duration or quality modified exercise-induced changes in weight, ghrelin or leptin. Moreover, the observed differences were not in the directions hypothesized. Future longitudinal studies including population-based samples using objective measures of sleep and long follow-up may help to clarify these relationships.
研究运动、睡眠、胃饥饿素和瘦素之间的横断面及纵向关系。
我们将居住在华盛顿州西部、年龄在50 - 75岁之间的173名绝经后久坐不动的超重女性（体重指数≥24.0 kg/m²且体脂>33%）随机分为设施及家庭基础的中等强度体育活动干预组或伸展对照组。在基线和12个月时评估空腹血浆胃饥饿素、瘦素、测量身高、体重及自我报告的睡眠情况。
在基线时，自我报告的睡眠指标与胃饥饿素或瘦素之间没有一致的横断面模式。与睡眠时长未改变的人相比，随访时睡眠较少的锻炼者与伸展者之间的体重减轻差异更大（-3.2 kg，95%置信区间（CI）-5.8，-0.5）。睡眠质量的改善与锻炼者和伸展者之间胃饥饿素增加（睡眠质量改善与相同：+115 pg/ml，95% CI +25，+206）和瘦素降低（睡眠质量改善与恶化：-5.7 ng/ml，95% CI -9.5，-1.5）的显著差异相关。
仅有有限证据表明睡眠时长或质量的变化会改变运动引起的体重、胃饥饿素或瘦素的变化。此外，观察到的差异并非如假设的方向。未来包括基于人群样本、使用客观睡眠测量方法及长期随访的纵向研究可能有助于阐明这些关系。
