产细胞毒素相关基因A的幽门螺杆菌与胃癌风险增加：韩国的一项巢式病例对照研究
CagA-producing Helicobacter pylori and increased risk of gastric cancer: a nested case-control study in Korea.
作者信息
Gwack J, Shin A, Kim C-S, Ko K-P, Kim Y, Jun J K, Bae J, Park S K, Hong Y-C, Kang D, Chang S-H, Shin H-R, Yoo K-Y
机构信息
Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-799, Korea.
出版信息
Br J Cancer. 2006 Sep 4;95(5):639-41. doi: 10.1038/sj.bjc.6603309. Epub 2006 Aug 8.
Abstract
In a nested-case control study of 100 cases of gastric cancer and 400 matched controls in relation to virulence factors of Helicobacter pylori in a Korean cohort, CagA seropositivity was significantly associated with a higher risk of gastric cancer among H. pylori-infected subjects (OR=3.57, 95% CI 1.05-12.14).
摘要
在一项针对韩国队列中100例胃癌病例和400例匹配对照进行的巢式病例对照研究中，研究幽门螺杆菌毒力因子与胃癌的关系，结果显示，在幽门螺杆菌感染的受试者中，细胞毒素相关基因A（CagA）血清阳性与患胃癌的较高风险显著相关（比值比=3.57，95%置信区间1.05 - 12.14）。
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