Dhar Suman Kumar, Soni Rajesh K, Das Bimal K, Mukhopadhyay Gauranga
Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India.
Mol Cell Biochem. 2003 Nov;253(1-2):207-15. doi: 10.1023/a:1026051530512.
Although Helicobacter pylori infects 50% of the total human population, only a small fraction of the infected people suffer from severe diseases like peptic ulcers and gastric adenocarcinoma. H. pylori strains, host genotypes and environmental factors play important role in deciding the extent and severity of the gastroduodenal diseases. The bacteria has developed a unique set of virulence factors to survive in the extreme ecological niche of human stomach. Together these virulence factors make H. pylori one of the most successful human pathogenic bacteria colonizing more than half of the human population. Understanding the mechanism of action of the major H. pylori virulence factors will shed light into the molecular basis of its pathogenicity.
尽管幽门螺杆菌感染了全球50%的人口，但只有一小部分感染者会患上消化性溃疡和胃腺癌等严重疾病。幽门螺杆菌菌株、宿主基因型和环境因素在决定胃十二指肠疾病的范围和严重程度方面起着重要作用。这种细菌已经形成了一套独特的毒力因子，以便在人类胃部的极端生态位中生存。这些毒力因子共同使幽门螺杆菌成为最成功的人类病原菌之一，感染了超过一半的人口。了解幽门螺杆菌主要毒力因子的作用机制将有助于揭示其致病性的分子基础。
