Holmes Laurens, Rios Jasmine, Berice Betyna, Benson Jacqueline, Bafford Nastocia, Parson Kadedrah, Halloran Daniel
Nemours Healthcare System for Children, Wilmington, DE 19803, USA.
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Medicines (Basel). 2021 Jan 5;8(1):1. doi: 10.3390/medicines8010001.
() is a bacterial pathogen implicated in gastritis, gastric ulceration, and gastric carcinoma. This study aimed to synthesize literature in providing evidence on the causative role of in gastric carcinoma development. This study is based on assessing public literature using an applied meta-analysis, namely, quantitative evidence synthesis (QES). The analytic procedure uses DerSimonian-Laird, including assessing heterogeneity. The QES also utilizes meta-regression and the environmental effect associated with in gastric cancer development. Eighteen studies are included in the QES. There is increased prevalence of exposure among the cases. The heterogeneity between the CES and individual effect sizes is also significant. Despite controlling for the confoundings, there is increased exposure to among the gastric cancer cases, regardless of the differences in the geographic location. in this synthesized literature illustrates the contributory role of this microbe in gastric carcinoma. Additionally, regardless of geographic locale, namely, South Korea or Spain, is implicated in gastric cancer development.
（）是一种与胃炎、胃溃疡和胃癌相关的细菌病原体。本研究旨在综合文献，为（）在胃癌发生中的致病作用提供证据。本研究基于使用应用荟萃分析，即定量证据综合（QES）来评估公共文献。分析程序采用DerSimonian-Laird法，包括评估异质性。QES还利用元回归以及与（）在胃癌发生中相关的环境效应。QES纳入了18项研究。病例中（）暴露的患病率增加。CES与个体效应大小之间的异质性也很显著。尽管对混杂因素进行了控制，但无论地理位置如何差异，胃癌病例中（）的暴露都有所增加。本综合文献中的（）说明了这种微生物在胃癌中的促成作用。此外，无论地理位置是韩国还是西班牙，（）都与胃癌发生有关。
