Ramachandran A, Snehalatha C, Sivasankari S, Hitman G A, Vijay V
Diabetes Research Centre and MV Hospital for Diabetes, WHO Collaborating Centre for Research, Education and Training in Diabetes, Royapuram, Chennai, India.
J Assoc Physicians India. 2007 Aug;55:560-2.
Familial aggregation of type 2 diabetes and its vascular complications is strong in Indians. In this study, we have analysed whether the age of the parent at birth of the offspring had any influence on the age at diagnosis of diabetes and age at onset of microvascular complications in the diabetic offspring.
Families with either a type 2 diabetic father or mother and a type 2 diabetic offspring, all of whom had been tested at our centre were included in this study (n = 300, father--122, mother--178, offspring male --201, female--99). Anthropometric details, age at diagnosis of diabetes, age at onset of complications and duration of diabetes were recorded. All relevant clinical and investigatory tests were done and appropriate statistical analyses were done.
Age at onset of diabetes was lower in the offspring than in their parents at least by a decade. The age at diagnosis of diabetes in the offspring was determined inversely by the age of the parent at childbirth (p<0.001) and positively by the age of onset of diabetes and the presence of complications in the parents (both p<0.0001). Moreover, the age at diagnosis of complications in the offspring were determined inversely by the age of the parent at childbirth (p=0.0001) and positively by the age of onset of complications in the parents (p=0.0009).
A younger parental age at childbirth was protective to the offspring in that the offspring developed diabetes and the complications at an older age.
2型糖尿病及其血管并发症在印度人群中具有很强的家族聚集性。在本研究中，我们分析了子代出生时父母的年龄是否会对糖尿病子代的糖尿病诊断年龄及微血管并发症发病年龄产生影响。
本研究纳入了父亲或母亲为2型糖尿病患者且子代也为2型糖尿病患者的家庭，所有研究对象均在我们中心接受过检测（n = 300，父亲122例，母亲178例，子代男性201例，女性99例）。记录人体测量细节、糖尿病诊断年龄、并发症发病年龄及糖尿病病程。进行了所有相关的临床和检查测试，并进行了适当的统计分析。
子代糖尿病发病年龄比其父母至少小十岁。子代糖尿病诊断年龄与父母生育时的年龄呈负相关（p<0.001），与父母糖尿病发病年龄及并发症的存在呈正相关（均p<0.0001）。此外，子代并发症诊断年龄与父母生育时的年龄呈负相关（p = 0.0001），与父母并发症发病年龄呈正相关（p = 0.0009）。
父母生育时年龄较小对后代具有保护作用，因为后代患糖尿病及并发症的年龄较大。
