Christensen T
Institute of Medical Microbiology and Immunology, University of Aarhus, Denmark.
Int MS J. 2007 Jun;14(2):41-7.
Environmental factors operate on a background of genetic susceptibility in MS pathogenesis; the human herpesviruses (HHV) are likely candidates for such factors. HHV share a number of properties: they are almost ubiquitous, they are highly prevalent worldwide, they all cause latent infections and they are capable of reactivation. Epstein Barr virus (EBV), HHV-6A and varicella zoster virus (VZV) are consistently linked with MS, particularly with respect to epidemiology, antibody responses in serum (EBV) and cerebrospinal fluid (EBV and HHV-6A), and with MS exacerbations that are associated with viral reactivation (VZV, HHV-6A and EBV). HHV have the potential for a causal role in MS--they may be key players in the disease process--and this role could be mediated through several direct or indirect mechanisms.
在多发性硬化症（MS）发病机制中，环境因素在遗传易感性的背景下起作用；人类疱疹病毒（HHV）很可能是这类因素的候选者。HHV具有一些共同特性：它们几乎无处不在，在全球高度流行，都会引起潜伏感染，并且能够重新激活。爱泼斯坦-巴尔病毒（EBV）、HHV-6A和水痘带状疱疹病毒（VZV）一直与MS相关，特别是在流行病学、血清（EBV）和脑脊液（EBV和HHV-6A）中的抗体反应方面，以及与病毒重新激活相关的MS病情加重（VZV、HHV-6A和EBV）方面。HHV在MS中具有因果作用的可能性——它们可能是疾病过程中的关键因素——并且这种作用可能通过几种直接或间接机制介导。
