Kashtan Clifford E
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Pediatr Transplant. 2006 Sep;10(6):651-7. doi: 10.1111/j.1399-3046.2006.00528.x.
For pediatric kidney transplant physicians, two aspects of Alport syndrome set the disease apart from other causes of terminal renal failure. First, an understanding of the genetics of Alport syndrome is needed to make appropriate decisions regarding potential related kidney donors to Alport patients requiring renal transplantation. Second, renal transplantation for Alport syndrome may be complicated by post-transplant anti-GBM nephritis, a problem that is nearly unique to this disease. This review discusses these aspects of Alport syndrome and attempts to provide rational recommendations for clinicians.
对于儿科肾移植医生而言，奥尔波特综合征的两个方面使其有别于终末期肾衰竭的其他病因。首先，需要了解奥尔波特综合征的遗传学知识，以便就可能与需要肾移植的奥尔波特综合征患者相关的肾脏供体做出恰当决策。其次，奥尔波特综合征患者肾移植可能会并发移植后抗肾小球基底膜肾炎，这几乎是该疾病独有的问题。本综述讨论了奥尔波特综合征的这些方面，并试图为临床医生提供合理建议。
