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兔眼结膜下注射西妥昔单抗的局部眼安全性。

Local ocular safety of the subconjunctival injection of cetuximab in rabbits.

机构信息

Eye Research Center, The Five Senses Health Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Department of Ophthalmology, Long School of Medicine, UT Health San Antonio, San Antonio, TX, USA.

出版信息

BMC Ophthalmol. 2023 Apr 13;23(1):155. doi: 10.1186/s12886-023-02893-6.

DOI:10.1186/s12886-023-02893-6
PMID:37055797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10103399/
Abstract

BACKGROUND

To evaluate the safety of different doses of subconjunctival cetuximab in rabbits.

METHODS

After general anesthesia rabbits received a subconjunctival injection of 2.5 mg in 0.5 ml, 5 mg in 1 ml, and 10 mg in 2 ml of cetuximab in their right eyes (two rabbits in each group). A similar volume of normal saline solution was injected subconjunctivally in the left eyes. The histopathologic changes were evaluated after enucleation with the aid of H&E staining.

RESULTS

No significant difference were observed between the treated and control eyes in terms of conjunctival inflammation, goblet cell density, or limbal blood vessel density for all administered doses of cetuximab.

CONCLUSION

Subconjunctival injection of cetuximab with the administrated doses in rabbit eyes are safe.

摘要

背景

评估不同剂量的兔眼结膜下西妥昔单抗的安全性。

方法

全身麻醉后，将 2.5mg 西妥昔单抗溶于 0.5ml 溶液、5mg 西妥昔单抗溶于 1ml 溶液和 10mg 西妥昔单抗溶于 2ml 溶液，分别右眼结膜下注射（每组 2 只兔）。左眼结膜下注射等体积生理盐水。眼球摘除后，用 H&E 染色评估组织病理学变化。

结果

在结膜炎症、杯状细胞密度或角膜缘血管密度方面，所有西妥昔单抗给药剂量的治疗眼与对照眼之间均无显著差异。

结论

兔眼结膜下注射西妥昔单抗在给予的剂量下是安全的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439c/10103399/a52452c381ae/12886_2023_2893_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439c/10103399/86cf0d51799f/12886_2023_2893_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439c/10103399/da1af1f2193a/12886_2023_2893_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439c/10103399/344decd7b3fb/12886_2023_2893_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439c/10103399/a52452c381ae/12886_2023_2893_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439c/10103399/86cf0d51799f/12886_2023_2893_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439c/10103399/da1af1f2193a/12886_2023_2893_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439c/10103399/344decd7b3fb/12886_2023_2893_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/439c/10103399/a52452c381ae/12886_2023_2893_Fig4_HTML.jpg

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