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眼睑皮肤黑色素瘤

Cutaneous melanomas of the eyelid.

作者信息

Boulos Patrick R, Rubin Peter A D

机构信息

Oculofacial and Orbit Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA.

出版信息

Semin Ophthalmol. 2006 Jul-Sep;21(3):195-206. doi: 10.1080/08820530500353864.

Abstract

Cutaneous eyelid melanomas are very rare lesions. The lentiginous subtypes are the most frequent melanocytic lesions of the eyelid and can be likened to conjunctival melanocytic lesions like PAM, PAM with atypia and conjunctival melanoma. Compared to melanomas elsewhere on the body, eyelid melanomas have special considerations. Eyelid skin is very thin, the mucocutaneous junction at the lid margin can affect prognosis, the lymphatic drainage pattern is very variable and there is an inherent difficulty to excise wide margins without sacrificing important structures. A customized excision approach, using tissue-sparing "Slow-Mohs" technique, is suggested. Sentinel lymph node dissection has an evolving therapeutic role but remains controversial.

摘要

眼睑皮肤黑色素瘤是非常罕见的病变。雀斑样亚型是眼睑最常见的黑素细胞病变,可类似于结膜黑素细胞病变,如原发性获得性黑素沉着症、非典型原发性获得性黑素沉着症和结膜黑色素瘤。与身体其他部位的黑色素瘤相比,眼睑黑色素瘤有特殊的考量因素。眼睑皮肤非常薄,睑缘的黏膜皮肤交界处会影响预后,淋巴引流模式非常多变,而且在不牺牲重要结构的情况下进行广泛切除存在内在困难。建议采用保留组织的“慢速莫氏”技术的定制切除方法。前哨淋巴结清扫术的治疗作用不断演变,但仍存在争议。

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